Disease discovery

Aims and targets

 - Disease mechanisms

 - Disease genes/proteins

 - Expression profiles

 - Macromolecular modeling

 - Homology modeling

 

Discipline

 - Functional genomics

 - Proteomics

 - Bioinformatics

Target identification

Aims and targets

 - Target type and "drugability"

 - Computer aided drug design (binding site mapping and

 - Detection of biomarkers (genomic profiling, transcriptional profiling)

 - Treatment response prediction)

 

Discipline

 - Structural biology

 - Rational drug discovery

 - Computional chemistry

Target validation

Aims and targets

 - Drug response in patient -derived tumour xenografts (in vitro tests)

 - Animal based in vivo tests

 

Discipline

 - Chemical biology

 - Toxicogenomics

Screening

Aims and targets

 - Compound libraries

 - "Hits" confirmation

 

Discipline

 - Combinatorial chemistry

Lead optimization

Aims and targets

 - Animal models

 - Toxicological examinations

 - Formulation and delivery

 

Discipline

 - Physical chemistry

 - Medicinal chemistry

 - Pharmacogenomics

Development

Aims and targets

 - Preclinical data package

 

Clinical trial

Aims and targets

 - Phase I (healthy volunteers)

 - Phase II (preliminary data in patients)

 - Phase III (FDA approval)

 

Discipline

 - Pharmacogenomics

Marketing

Aims and targets

 - New Drug Application

 - Phase IV (safety and long-term risks)