Drug Development
DISEASE DISCOVERY
AIMS AND TARGETS
- Disease mechanisms
- Disease genes/proteins
- Expression profiles
- Macromolecular modeling
- Homology modeling
DISCIPLINE
- Functional genomics
- Proteomics
- Bioinformatics
TARGET IDENTIFICATION
AIMS AND TARGETS
- Target type and “drugability”
- Computer aided drug design (binding site mapping and
- Detection of biomarkers (genomic profiling, transcriptional profiling)
- Treatment response prediction)
DISCIPLINE
- Structural biology
- Rational drug discovery
- Computional chemistry
TARGET VALIDATION
AIMS AND TARGETS
- Drug response in patient -derived tumour xenografts (in vitro tests)
- Animal based in vivo tests
DISCIPLINE
- Chemical biology
- Toxicogenomics
SCREENING
AIMS AND TARGETS
- Compound libraries
- “Hits” confirmation
DISCIPLINE
- Combinatorial chemistry
LEAD OPTIMIZATION
AIMS AND TARGETS
- Animal models
- Toxicological examinations
- Formulation and delivery
DISCIPLINE
- Physical chemistry
- Medicinal chemistry
- Pharmacogenomics
DEVELOPMENT
AIMS AND TARGETS
- Preclinical data package
CLINICAL TRIAL
AIMS AND TARGETS
- Phase I (healthy volunteers)
- Phase II (preliminary data in patients)
- Phase III (FDA approval)
DISCIPLINE
- Pharmacogenomics
MARKETING
AIMS AND TARGETS
- New Drug Application
- Phase IV (safety and long-term risks)